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Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production

During the immune response to pathogens and autoantigens, CD8 T cells are exposed to numerous inflammatory agents including the cytokine IL-12. Previous studies have focused on how IL-12 regulates T cell functions when present during or after the activation of the T cell receptor (TCR). However, rec...

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Detalhes bibliográficos
Publicado no:Mol Immunol
Main Authors: Vacaflores, Aldo, Freedman, Samantha N., Chapman, Nicole M., Houtman, Jon C.D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201458/
https://ncbi.nlm.nih.gov/pubmed/27883938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2016.11.008
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