CD161(++)CD8(+) T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

CD161(++)CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells an...

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Hlavní autoři: Ussher, James E, Bilton, Matthew, Attwod, Emma, Shadwell, Jonathan, Richardson, Rachel, de Lara, Catherine, Mettke, Elisabeth, Kurioka, Ayako, Hansen, Ted H, Klenerman, Paul, Willberg, Christian B
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Innate Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947164/
https://ncbi.nlm.nih.gov/pubmed/24019201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343509
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