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The role of the LAT-PLC-γ1 interaction in T regulatory cell function
The interaction between the linker for activation of T cells (LAT) with phospholipase C (PLC-γ1) is important for T cell receptor (TCR)-mediated Ca(2+) signaling and MAPK activation. Knock-in mice harboring a mutation at the PLC-γ1 binding site (Y136) of LAT develop a severe lymphoproliferative synd...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3646363/ https://ncbi.nlm.nih.gov/pubmed/20130215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902876 |
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