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The Importance of LAT in the Activation, Homeostasis, and Regulatory Function of T Cells

LAT (linker for activation of T cells) is a transmembrane adaptor protein that plays an essential role in TCR-mediated signaling and thymocyte development. Because LAT-deficient mice have an early block in thymocyte development, we utilized an inducible system to delete LAT in primary T cells to stu...

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Autors principals: Shen, Shudan, Chuck, Mariana I., Zhu, Minghua, Fuller, Deirdre M., Yang, Chih-wen Ou, Zhang, Weiguo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975163/
https://ncbi.nlm.nih.gov/pubmed/20837489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145052
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