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The Importance of the Erk Pathway in the Development of LAT-Mediated Autoimmunity
The ability of the transmembrane adaptor protein LAT to regulate T cell development, activation, survival, and homeostasis depends upon phosphorylation of its multiple tyrosine residues. The mutation of tyrosine 136 on LAT abrogates its interaction with PLC-γ1, causing severe ramifications on TCR-me...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548449/ https://ncbi.nlm.nih.gov/pubmed/22984075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201380 |
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