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High-Content pSTAT3/1 Imaging Assays to Screen for Selective Inhibitors of STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is hyperactivated in most cancers and represents a plausible therapeutic target. In the absence of STAT3-selective small-molecule inhibitors, we sought to develop pSTAT3/1 high-content imaging (HCS) assays...

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Bibliografische gegevens
Hoofdauteurs: Johnston, Paul A., Sen, Malabika, Hua, Yun, Camarco, Daniel, Shun, Tong Ying, Lazo, John S., Grandis, Jennifer R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mary Ann Liebert, Inc. 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934522/
https://ncbi.nlm.nih.gov/pubmed/24127660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2013.524
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