Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis

Chronic kidney disease progression can be predicted based on the degree of tubular atrophy, which is the result of proximal tubule apoptosis. The Na(+)/H(+) exchanger NHE1 regulates proximal tubule cell survival through interaction with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], but pathophy...

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Main Authors: Khan, Shenaz, Abu Jawdeh, Bassam G., Goel, Monu, Schilling, William P., Parker, Mark D., Puchowicz, Michelle A., Yadav, Satya P., Harris, Raymond C., El-Meanawy, Ashraf, Hoshi, Malcolm, Shinlapawittayatorn, Krekwit, Deschênes, Isabelle, Ficker, Eckhard, Schelling, Jeffrey R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934167/
https://ncbi.nlm.nih.gov/pubmed/24531551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71863
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