Phosphoinositide Binding Differentially Regulates NHE1 Na(+)/H(+) Exchanger-dependent Proximal Tubule Cell Survival

Tubular atrophy predicts chronic kidney disease progression, and is caused by proximal tubular epithelial cell (PTC) apoptosis. The normally quiescent Na(+)/H(+) exchanger-1 (NHE1) defends against PTC apoptosis, and is regulated by PI(4,5)P(2) binding. Because of the vast array of plasma membrane li...

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Hlavní autoři: Abu Jawdeh, Bassam G., Khan, Shenaz, Deschênes, Isabelle, Hoshi, Malcolm, Goel, Monu, Lock, Jeffrey T., Shinlapawittayatorn, Krekwit, Babcock, Gerald, Lakhe-Reddy, Sujata, DeCaro, Garren, Yadav, Satya P., Mohan, Maradumane L., Naga Prasad, Sathyamangla V., Schilling, William P., Ficker, Eckhard, Schelling, Jeffrey R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234923/
https://ncbi.nlm.nih.gov/pubmed/22020933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.212845
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