A Novel Strategy Using Cardiac Sodium Channel Polymorphic Fragments to Rescue Trafficking Deficient SCN5A Mutations

BACKGROUND: Brugada Syndrome (BrS) is associated with mutations in the cardiac sodium channel (Na(v)1.5). We previously reported that the function of a trafficking-deficient BrS Na(v)1.5 mutation, R282H, could be restored by co-expression with the sodium channel polymorphism H558R. Here, we tested t...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shinlapawittayatorn, Krekwit, Dudash, Lynn A., Du, Xi X., Heller, Lisa, Poelzing, Steven, Ficker, Eckhard, Deschênes, Isabelle
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197758/
https://ncbi.nlm.nih.gov/pubmed/21840964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.111.960633
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