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A Novel Strategy Using Cardiac Sodium Channel Polymorphic Fragments to Rescue Trafficking Deficient SCN5A Mutations
BACKGROUND: Brugada Syndrome (BrS) is associated with mutations in the cardiac sodium channel (Na(v)1.5). We previously reported that the function of a trafficking-deficient BrS Na(v)1.5 mutation, R282H, could be restored by co-expression with the sodium channel polymorphism H558R. Here, we tested t...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197758/ https://ncbi.nlm.nih.gov/pubmed/21840964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.111.960633 |
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