Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis

Chronic kidney disease progression can be predicted based on the degree of tubular atrophy, which is the result of proximal tubule apoptosis. The Na(+)/H(+) exchanger NHE1 regulates proximal tubule cell survival through interaction with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], but pathophy...

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Detalhes bibliográficos
Main Authors: Khan, Shenaz, Abu Jawdeh, Bassam G., Goel, Monu, Schilling, William P., Parker, Mark D., Puchowicz, Michelle A., Yadav, Satya P., Harris, Raymond C., El-Meanawy, Ashraf, Hoshi, Malcolm, Shinlapawittayatorn, Krekwit, Deschênes, Isabelle, Ficker, Eckhard, Schelling, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934167/
https://ncbi.nlm.nih.gov/pubmed/24531551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71863
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