Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis

Chronic kidney disease progression can be predicted based on the degree of tubular atrophy, which is the result of proximal tubule apoptosis. The Na(+)/H(+) exchanger NHE1 regulates proximal tubule cell survival through interaction with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], but pathophy...

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Autors principals: Khan, Shenaz, Abu Jawdeh, Bassam G., Goel, Monu, Schilling, William P., Parker, Mark D., Puchowicz, Michelle A., Yadav, Satya P., Harris, Raymond C., El-Meanawy, Ashraf, Hoshi, Malcolm, Shinlapawittayatorn, Krekwit, Deschênes, Isabelle, Ficker, Eckhard, Schelling, Jeffrey R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934167/
https://ncbi.nlm.nih.gov/pubmed/24531551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71863
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