Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides.
Two 19-base-long oligonucleotides were synthesized, one complementary to the normal human beta-globin gene (beta A) and one complementary to the sickle cell beta-globin gene (beta S). The nonadecanucleotides were radioactively labeled and used as probes in DNA hybridization. Under appropriate hybrid...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1983
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393356/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.1.278 |
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