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Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides.

Two 19-base-long oligonucleotides were synthesized, one complementary to the normal human beta-globin gene (beta A) and one complementary to the sickle cell beta-globin gene (beta S). The nonadecanucleotides were radioactively labeled and used as probes in DNA hybridization. Under appropriate hybrid...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Conner, B J, Reyes, A A, Morin, C, Itakura, K, Teplitz, R L, Wallace, R B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1983
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC393356/
https://ncbi.nlm.nih.gov/pubmed/6572002
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