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Oligonucleotide directed mutagenesis of the human beta-globin gene: a general method for producing specific point mutations in cloned DNA.

A nonadecanucleotide has been used both as a site specific mutagen to introduce a T leads to A transversion mutation in the human beta-globin gene cloned in pBR322 as well as a probe to screen transformed colonies for the desired mutant. The specificity of the oligonucleotide as a mutagen and as a h...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Wallace, R B, Schold, M, Johnson, M J, Dembek, P, Itakura, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 1981
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327381/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7279669/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/9.15.3647
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