From Structure to Systems: High-Resolution, Quantitative Genetic Analysis of RNA Polymerase II

RNA polymerase II (RNAPII) lies at the core of dynamic control of gene expression. Using 53 RNAPII point mutants, we generated a point mutant epistatic miniarray profile (pE-MAP) comprising ~60,000 quantitative genetic interactions in Saccharomyces cerevisiae. This analysis enabled functional assign...

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Main Authors: Braberg, Hannes, Jin, Huiyan, Moehle, Erica A., Chan, Yujia A., Wang, Shuyi, Shales, Michael, Benschop, Joris J., Morris, John H., Qiu, Chenxi, Hu, Fuqu, Tang, Leung K., Fraser, James S., Holstege, Frank C.P., Hieter, Philip, Guthrie, Christine, Kaplan, Craig D., Krogan, Nevan J.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932829/
https://ncbi.nlm.nih.gov/pubmed/23932120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.033
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