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From Structure to Systems: High-Resolution, Quantitative Genetic Analysis of RNA Polymerase II
RNA polymerase II (RNAPII) lies at the core of dynamic control of gene expression. Using 53 RNAPII point mutants, we generated a point mutant epistatic miniarray profile (pE-MAP) comprising ~60,000 quantitative genetic interactions in Saccharomyces cerevisiae. This analysis enabled functional assign...
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| Autori principali: | , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932829/ https://ncbi.nlm.nih.gov/pubmed/23932120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.033 |
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