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Optimization of Antitumor Modulators of Pre-mRNA Splicing
The spliceosome regulates pre-mRNA splicing, which is a critical process in normal mammalian cells. Recently recurrent mutations in numerous spliceosomal proteins have been associated with a number of cancers. Previously natural product antitumor agents have been shown to interact with one of the pr...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932738/ https://ncbi.nlm.nih.gov/pubmed/24325474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401370h |
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