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Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates

The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel pharmacodynamic assays that facilitate drug discovery and development of this intriguing class of innovative therap...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Pharmacol Res Perspect
Main Authors: Shi, Yihui, Joyner, Amanda S, Shadrick, William, Palacios, Gustavo, Lagisetti, Chandraiah, Potter, Philip M, Sambucetti, Lidia C, Stamm, Stefan, Webb, Thomas R
פורמט: Artigo
שפה:Inglês
יצא לאור: John Wiley & Sons, Ltd 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492733/
https://ncbi.nlm.nih.gov/pubmed/26171237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.158
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