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A Triple Exon-Skipping Luciferase Reporter Assay Identifies A New CLK Inhibitor Pharmacophore
The splicing of pre-mRNA is a critical process in normal cells and is deregulated in cancer. Compounds that modulate this process have recently been shown to target a specific vulnerability in tumors. We have developed a novel cell-based assay that specifically activates luciferase in cells exposed...
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5295499/ https://ncbi.nlm.nih.gov/pubmed/28049589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.12.056 |
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