An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Agents that modulate pre-mRNA splicing are of interest in multiple therapeutic areas, including cancer. We report our recent screening results with the application of a cell-based Triple Exon Skipping Luciferase Reporter (TESLR) using a library that is composed of FDA approved drugs, clinical compou...

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Veröffentlicht in:PLoS One
Hauptverfasser: Shi, Yihui, Bray, Walter, Smith, Alexander J., Zhou, Wei, Calaoagan, Joy, Lagisetti, Chandraiah, Sambucetti, Lidia, Crews, Phillip, Lokey, R. Scott, Webb, Thomas R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259758/
https://ncbi.nlm.nih.gov/pubmed/32469945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233672
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