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Radiosynthesis of Antitumor Spliceosome Modulators

A set of novel antitumor agents (the sudemycins) has recently been described that are analogs of the natural product FR901464. We report the radiosynthesis of two of these antitumor drug lead compounds, using a three step procedure: 1) ester hydrolysis, 2) Lindlar’s catalyst/tritium gas to give a (S...

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Detalhes bibliográficos
Main Authors: Goronga, Tinopiwa, Boyd, Vincent A., Lagisetti, Chandraiah, Jeffries, Cynthia, Webb, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105125/
https://ncbi.nlm.nih.gov/pubmed/21531567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2011.04.008
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