Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Somatic mutations in spliceosome genes are detectable in ∼50% of patients with myelodysplastic syndromes (MDS). We hypothesize that cells harbouring spliceosome gene mutations have increased sensitivity to pharmacological perturbation of the spliceosome. We focus on mutant U2AF1 and utilize sudemyci...

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Vydáno v:Nat Commun
Hlavní autoři: Shirai, Cara Lunn, White, Brian S., Tripathi, Manorama, Tapia, Roberto, Ley, James N., Ndonwi, Matthew, Kim, Sanghyun, Shao, Jin, Carver, Alexa, Saez, Borja, Fulton, Robert S., Fronick, Catrina, O'Laughlin, Michelle, Lagisetti, Chandraiah, Webb, Thomas R., Graubert, Timothy A., Walter, Matthew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5227701/
https://ncbi.nlm.nih.gov/pubmed/28067246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14060
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