RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES

Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML). We used whole genome sequencing to perform an unbiased comprehensive screen to discover all the somatic mutations in a sAML sample and genotype...

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Main Authors: Graubert, Timothy A., Shen, Dong, Ding, Li, Okeyo-Owuor, Theresa, Lunn, Cara L., Shao, Jin, Krysiak, Kilannin, Harris, Christopher C., Koboldt, Daniel C., Larson, David E., McLellan, Michael D., Dooling, David J., Abbott, Rachel M., Fulton, Robert S., Schmidt, Heather, Kalicki-Veizer, Joelle, O’Laughlin, Michelle, Grillot, Marcus, Baty, Jack, Heath, Sharon, Frater, John L., Nasim, Talat, Link, Daniel C., Tomasson, Michael H., Westervelt, Peter, DiPersio, John F., Mardis, Elaine R., Ley, Timothy J., Wilson, Richard K., Walter, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247063/
https://ncbi.nlm.nih.gov/pubmed/22158538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.1031
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