Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes

Alterations in DNA methylation have been implicated in the pathogenesis of myelodysplastic syndromes (MDS), although the underlying mechanism remains largely unknown. Methylation of CpG dinucleotides is mediated by DNA methyltransferases, including DNMT1, DNMT3A, and DNMT3B. DNMT3A mutations have re...

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Main Authors: Walter, Matthew J., Ding, Li, Shen, Dong, Shao, Jin, Grillot, Marcus, McLellan, Michael, Fulton, Robert, Schmidt, Heather, Kalicki-Veizer, Joelle, O’Laughlin, Michelle, Kandoth, Cyriac, Baty, Jack, Westervelt, Peter, DiPersio, John F., Mardis, Elaine R, Wilson, Richard K., Ley, Timothy J., Graubert, Timothy A.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202965/
https://ncbi.nlm.nih.gov/pubmed/21415852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.44
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