Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes

Alterations in DNA methylation have been implicated in the pathogenesis of myelodysplastic syndromes (MDS), although the underlying mechanism remains largely unknown. Methylation of CpG dinucleotides is mediated by DNA methyltransferases, including DNMT1, DNMT3A, and DNMT3B. DNMT3A mutations have re...

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Autors principals: Walter, Matthew J., Ding, Li, Shen, Dong, Shao, Jin, Grillot, Marcus, McLellan, Michael, Fulton, Robert, Schmidt, Heather, Kalicki-Veizer, Joelle, O’Laughlin, Michelle, Kandoth, Cyriac, Baty, Jack, Westervelt, Peter, DiPersio, John F., Mardis, Elaine R, Wilson, Richard K., Ley, Timothy J., Graubert, Timothy A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202965/
https://ncbi.nlm.nih.gov/pubmed/21415852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.44
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