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Anti-tumor Compounds Based on a Natural Product Consensus Pharmacophore
We report the design and highly enantioselective synthesis of a potent analog of the spliceosome inhibitor FR901464, based on a non-natural product scaffold. The design of this compound was facilitated by a pharmacophore hypothesis that assumed key interaction types that are common to FR901464 and a...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701350/ https://ncbi.nlm.nih.gov/pubmed/18788726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8006195 |
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