Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1)

PURPOSE: In addition to mutated BCR-ABL1 kinase, the organic cation transporter 1 (OCT1, encoded by SLC22A1) has been considered to contribute to imatinib resistance in patients with chronic myeloid leukemia (CML). Since data are conflicting as to whether OCT1 transports imatinib and may serve as cl...

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Bibliographic Details
Main Authors: Nies, Anne T., Schaeffeler, Elke, van der Kuip, Heiko, Cascorbi, Ingolf, Bruhn, Oliver, Kneba, Michael, Pott, Christiane, Hofmann, Ute, Volk, Christopher, Hu, Shuiying, Baker, Sharyn D., Sparreboom, Alex, Ruth, Peter, Koepsell, Hermann, Schwab, Matthias
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932302/
https://ncbi.nlm.nih.gov/pubmed/24352644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1999
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