Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation

Adipose tissue (AT) of obese mice and humans accumulates immune cells, which secrete cytokines that can promote insulin resistance. AT macrophages (ATMs) are thought to originate from bone marrow-derived monocytes, which infiltrate the tissue from the circulation. Here we show that a major fraction...

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Hauptverfasser: Amano, Shinya U., Cohen, Jessica L., Vangala, Pranitha, Tencerova, Michaela, Nicoloro, Sarah M., Yawe, Joseph C., Shen, Yuefei, Czech, Michael P., Aouadi, Myriam
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931314/
https://ncbi.nlm.nih.gov/pubmed/24374218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.017
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