The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac β-Myosin

The human hypertrophic cardiomyopathy mutation R453C results in one of the more severe forms of the myopathy. Arg-453 is found in a conserved surface loop of the upper 50-kDa domain of the myosin motor domain and lies between the nucleotide binding pocket and the actin binding site. It connects to t...

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Autores principales: Bloemink, Marieke, Deacon, John, Langer, Stephen, Vera, Carlos, Combs, Ariana, Leinwand, Leslie, Geeves, Michael A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931073/
https://ncbi.nlm.nih.gov/pubmed/24344137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.511204
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