γ-Secretase Associated with Lipid Rafts: MULTIPLE INTERACTIVE PATHWAYS IN THE STEPWISE PROCESSING OF β-CARBOXYL-TERMINAL FRAGMENT

γ-Secretase generates amyloid β-protein (Aβ), a pathogenic molecule in Alzheimer disease, through the intramembrane cleavage of the β-carboxyl-terminal fragment (βCTF) of β-amyloid precursor protein. We previously showed the framework of the γ-secretase cleavage, i.e. the stepwise successive process...

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Autori principali: Matsumura, Nobutaka, Takami, Mako, Okochi, Masayasu, Wada-Kakuda, Satoko, Fujiwara, Hitomi, Tagami, Shinji, Funamoto, Satoru, Ihara, Yasuo, Morishima-Kawashima, Maho
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931069/
https://ncbi.nlm.nih.gov/pubmed/24375443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510131
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