Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3

Amyloid β-peptide (Aβ) pathology is an invariant feature of Alzheimer disease, preceding any detectable clinical symptoms by more than a decade. To this end, we seek to identify agents that can reduce Aβ levels in the brain via novel mechanisms. We found that (20S)-Rg3, a triterpene natural compound...

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Bibliografische gegevens
Hoofdauteurs: Kang, Min Suk, Baek, Seung-Hoon, Chun, Yoon Sun, Moore, A. Zenobia, Landman, Natalie, Berman, Diego, Yang, Hyun Ok, Morishima-Kawashima, Maho, Osawa, Satoko, Funamoto, Satoru, Ihara, Yasuo, Di Paolo, Gilbert, Park, Jeong Hill, Chung, Sungkwon, Kim, Tae-Wan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
Onderwerpen:
Neurobiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774358/
https://ncbi.nlm.nih.gov/pubmed/23723072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445734
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