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γ-Secretase Associated with Lipid Rafts: MULTIPLE INTERACTIVE PATHWAYS IN THE STEPWISE PROCESSING OF β-CARBOXYL-TERMINAL FRAGMENT
γ-Secretase generates amyloid β-protein (Aβ), a pathogenic molecule in Alzheimer disease, through the intramembrane cleavage of the β-carboxyl-terminal fragment (βCTF) of β-amyloid precursor protein. We previously showed the framework of the γ-secretase cleavage, i.e. the stepwise successive process...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931069/ https://ncbi.nlm.nih.gov/pubmed/24375443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510131 |
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