γ-Secretase Associated with Lipid Rafts: MULTIPLE INTERACTIVE PATHWAYS IN THE STEPWISE PROCESSING OF β-CARBOXYL-TERMINAL FRAGMENT

γ-Secretase generates amyloid β-protein (Aβ), a pathogenic molecule in Alzheimer disease, through the intramembrane cleavage of the β-carboxyl-terminal fragment (βCTF) of β-amyloid precursor protein. We previously showed the framework of the γ-secretase cleavage, i.e. the stepwise successive process...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Matsumura, Nobutaka, Takami, Mako, Okochi, Masayasu, Wada-Kakuda, Satoko, Fujiwara, Hitomi, Tagami, Shinji, Funamoto, Satoru, Ihara, Yasuo, Morishima-Kawashima, Maho
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931069/
https://ncbi.nlm.nih.gov/pubmed/24375443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510131
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares