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Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.
Double-stranded RNA inhibits protein synthesis in at least two ways. It activates a protein kinase that blocks peptide chain initiation by phosphorylating the peptide chain initiation factor eIF-2 and also activates an endonuclease that inactivates different mRNAs at different rates. The protein kin...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1978
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393082/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/282611/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.12.5893 |
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