Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

Double-stranded RNA inhibits protein synthesis in at least two ways. It activates a protein kinase that blocks peptide chain initiation by phosphorylating the peptide chain initiation factor eIF-2 and also activates an endonuclease that inactivates different mRNAs at different rates. The protein kin...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Farrell, P J, Sen, G C, Dubois, M F, Ratner, L, Slattery, E, Lengyel, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1978
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393082/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/282611/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.12.5893
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