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Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

Double-stranded RNA inhibits protein synthesis in at least two ways. It activates a protein kinase that blocks peptide chain initiation by phosphorylating the peptide chain initiation factor eIF-2 and also activates an endonuclease that inactivates different mRNAs at different rates. The protein kin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Farrell, P J, Sen, G C, Dubois, M F, Ratner, L, Slattery, E, Lengyel, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1978
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393082/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/282611/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.12.5893
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