Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection

Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca(2+)/calmodulin(CaM)-dependent protein kinase II (CaMKII) and other kinases, while long-term depression (LTD) requires phosphatases. Here we found that LTD also requires CaMKII and its phospho-T286-induced “auton...

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Bibliografiske detaljer
Main Authors: Coultrap, Steven J., Freund, Ronald K., O’Leary, Heather, Sanderson, Jennifer L., Roche, Katherine W., Dell’Acqua1, Mark L., Bayer, K. Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930569/
https://ncbi.nlm.nih.gov/pubmed/24485660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.005
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