CaMKII “Autonomy” Is Required for Initiating But Not for Maintaining Neuronal Long-Term Information Storage

Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) “autonomy” (T286-autophosphorylation-induced Ca(2+)-independent activity) is required for long-term potentiation (LTP) and for learning and memory, as demonstrated by CaMKII T286A mutant mice. The >20-year-old hypothesis that CaMKII sti...

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Hauptverfasser: Buard, Isabelle, Coultrap, Steven J., Freund, Ronald K., Lee, Yong-Seok, Dell'Acqua, Mark L., Silva, Alcino J., Bayer, K. Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891520/
https://ncbi.nlm.nih.gov/pubmed/20554872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1469-10.2010
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