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Autonomous CaMKII requires further stimulation by Ca(2+)/calmodulin for enhancing synaptic strength
A hallmark feature of Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is generation of autonomous (Ca(2+)-independent) activity by T286 autophosphorylation. Biochemical studies have shown that “autonomous” CaMKII is ∼5-fold further stimulated by Ca(2+)/CaM, but demonstration of a physio...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Federation of American Societies for Experimental Biology
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4101658/ https://ncbi.nlm.nih.gov/pubmed/24843070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-250407 |
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