Autonomous CaMKII requires further stimulation by Ca(2+)/calmodulin for enhancing synaptic strength

A hallmark feature of Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is generation of autonomous (Ca(2+)-independent) activity by T286 autophosphorylation. Biochemical studies have shown that “autonomous” CaMKII is ∼5-fold further stimulated by Ca(2+)/CaM, but demonstration of a physio...

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Bibliografiske detaljer
Main Authors: Barcomb, Kelsey, Buard, Isabelle, Coultrap, Steven J., Kulbe, Jacqueline R., O'Leary, Heather, Benke, Timothy A., Bayer, K. Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2014
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101658/
https://ncbi.nlm.nih.gov/pubmed/24843070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-250407
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