Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥ 50% of tumours expressing the BRAF(V600E) oncoprotein(1,2). Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemuraf...

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Bibliographische Detailangaben
Hauptverfasser: Thakur, Meghna Das, Salangsang, Fernando, Landman, Allison S., Sellers, William R., Pryer, Nancy K., Levesque, Mitchell P., Dummer, Reinhard, McMahon, Martin, Stuart, Darrin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930354/
https://ncbi.nlm.nih.gov/pubmed/23302800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11814
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