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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥ 50% of tumours expressing the BRAF(V600E) oncoprotein(1,2). Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemuraf...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930354/ https://ncbi.nlm.nih.gov/pubmed/23302800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11814 |
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