Hypoxia-driven mechanism of vemurafenib resistance in melanoma

Melanoma is molecularly and structurally heterogeneous, with some tumor cells existing under hypoxic conditions. Our cell growth assays showed that under controlled hypoxic conditions, BRAF(V600E) melanoma cells rapidly became resistant to vemurafenib. By employing both a three-dimensional (3D) sphe...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Mol Cancer Ther
Päätekijät: Qin, Yong, Roszik, Jason, Chattopadhyay, Chandrani, Hashimoto, Yuuri, Liu, Chengwen, Cooper, Zachary A., Wargo, Jennifer A., Hwu, Patrick, Ekmekcioglu, Suhendan, Grimm, Elizabeth A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079683/
https://ncbi.nlm.nih.gov/pubmed/27458138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0963
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