Hypoxia-driven mechanism of vemurafenib resistance in melanoma

Melanoma is molecularly and structurally heterogeneous, with some tumor cells existing under hypoxic conditions. Our cell growth assays showed that under controlled hypoxic conditions, BRAF(V600E) melanoma cells rapidly became resistant to vemurafenib. By employing both a three-dimensional (3D) sphe...

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Publicat a:Mol Cancer Ther
Autors principals: Qin, Yong, Roszik, Jason, Chattopadhyay, Chandrani, Hashimoto, Yuuri, Liu, Chengwen, Cooper, Zachary A., Wargo, Jennifer A., Hwu, Patrick, Ekmekcioglu, Suhendan, Grimm, Elizabeth A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079683/
https://ncbi.nlm.nih.gov/pubmed/27458138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0963
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