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SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells
SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+) T cells and that is counteracted in SIV and HIV-2 by the Vpx accessory protein. The protein is a phosphohydrolase that lowers the concentration of deoxynucleoside triphosphates (dNTP), blocking rever...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929709/ https://ncbi.nlm.nih.gov/pubmed/24586870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089558 |
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