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A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse
The triphosphohydrolase SAMHD1 (sterile α motif and histidine-aspartate domain-containing protein 1) restricts HIV-1 replication in nondividing myeloid cells by depleting the dNTP pool, preventing reverse transcription. SAMHD1 is also reported to have ribonuclease activity that degrades the virus ge...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5247641/ https://ncbi.nlm.nih.gov/pubmed/27920203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743740 |
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