A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse

The triphosphohydrolase SAMHD1 (sterile α motif and histidine-aspartate domain-containing protein 1) restricts HIV-1 replication in nondividing myeloid cells by depleting the dNTP pool, preventing reverse transcription. SAMHD1 is also reported to have ribonuclease activity that degrades the virus ge...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Bloch, Nicolin, Gläsker, Sabine, Sitaram, Poojitha, Hofmann, Henning, Shepard, Caitlin N., Schultz, Megan L., Kim, Baek, Landau, Nathaniel R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Microbiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247641/
https://ncbi.nlm.nih.gov/pubmed/27920203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743740
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