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SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells

SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+) T cells and that is counteracted in SIV and HIV-2 by the Vpx accessory protein. The protein is a phosphohydrolase that lowers the concentration of deoxynucleoside triphosphates (dNTP), blocking rever...

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Detalhes bibliográficos
Main Authors: Zhang, Ruonan, Bloch, Nicolin, Nguyen, Laura A., Kim, Baek, Landau, Nathaniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929709/
https://ncbi.nlm.nih.gov/pubmed/24586870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089558
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