Monoclonal anti-β(1)-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment

Thermostabilized G protein-coupled receptors used as antigens for in vivo immunization have resulted in the generation of functional agonistic anti-β(1)-adrenergic (β(1)AR) receptor monoclonal antibodies (mAbs). The focus of this study was to examine the pharmacology of these antibodies to evaluate...

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Detalhes bibliográficos
Main Authors: Hutchings, Catherine J, Cseke, Gabriella, Osborne, Greg, Woolard, Jeanette, Zhukov, Andrei, Koglin, Markus, Jazayeri, Ali, Pandya-Pathak, Jahnavi, Langmead, Christopher J, Hill, Stephen J, Weir, Malcolm, Marshall, Fiona H.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929447/
https://ncbi.nlm.nih.gov/pubmed/24253107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27226
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