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A monoclonal antibody raised against a thermo-stabilised β(1)-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β(1)-adrenoceptors expressed in stable cell lines

Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turkey β(1)-adrenoceptor (β(1)AR-m23 StaR), on β(1)-ARs expressed in CHO-K1 or...

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Detalhes bibliográficos
Publicado no:Biochem Pharmacol
Main Authors: Soave, Mark, Cseke, Gabriella, Hutchings, Catherine J., Brown, Alastair J.H., Woolard, Jeanette, Hill, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770334/
https://ncbi.nlm.nih.gov/pubmed/29102678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.10.015
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