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A monoclonal antibody raised against a thermo-stabilised β(1)-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β(1)-adrenoceptors expressed in stable cell lines
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turkey β(1)-adrenoceptor (β(1)AR-m23 StaR), on β(1)-ARs expressed in CHO-K1 or...
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| Publié dans: | Biochem Pharmacol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier Science
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770334/ https://ncbi.nlm.nih.gov/pubmed/29102678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.10.015 |
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